Nonparametric inference for time-dependent incremental cost-effectiveness ratios

Statistical Inference for Costs and Incremental Cost - Effectiveness Ratios with Censored Data

Statistical Inference for Costs and Incremental Cost-Effectiveness Ratios with Censored Data. (May 2012) Shuai Chen, B.S., Peking University Co–Chairs of Advisory Committee: Dr. Hongwei Zhao Dr. Lan Zhou Cost-effectiveness analysis is widely conducted in the economic evaluation of new treatment options. In many clinical and observational studies of costs, data are often censored. Censoring brin...

Acceptance of health technology assessment submissions with incremental cost-effectiveness ratios above the cost-effectiveness threshold

OBJECTIVES In health technology assessment (HTA) agencies where cost-effectiveness plays a role in decision-making, an incremental cost-effectiveness ratio (ICER) threshold is often used to inform reimbursement decisions. The acceptance of submissions with ICERs higher than the threshold was assessed across different agencies and across indications, in order to inform future reimbursement submi...

Differences in Incremental Cost-Effectiveness Ratios for Common Versus Rare Conditions: A Case from Oncology

BACKGROUND Incremental cost-effectiveness ratios (ICERs) are used to assess the value for money of new drugs. Many believe that ICERs for drugs that treat rare diseases are much higher than those of common drugs. Our objective was to compare the proportion of ICERs that are cost effective for rare and common cancers. METHODS We used the Tufts Medical Center Cost-Effectiveness Analysis (CEA) R...

Estimating incremental cost-effectiveness ratios and their confidence intervals with different terminating events for survival time and costs.

Cost-effectiveness analysis (CEA) is an important component of the economic evaluation of new treatment options. In many clinical and observational studies of costs, censored data pose challenges to the CEA. We consider a special situation where the terminating events for the survival time and costs are different. Traditional methods for statistical inference offer no means for dealing with cen...

Incremental Cost-Effectiveness (ICE) Concepts